![]() ![]() ![]() "Our hope was that the DNA data might point to shared biological processes as candidates for involvement in synaesthesia." Professor Simon Fisher, Director of the Max Planck Institute, who led the research, said, "We knew from earlier studies by the Cambridge team that no single gene can account for this intriguing trait even families who experience the same form of synesthesia are likely to differ in terms of specific genetic explanations," said Fisher. Axonogenesis is a key process enabling brain cells to wire up to their correct partners.Ĭombining families to uncover biological processes While the highlighted DNA variants differed between the three families, a common theme emerged to connect them: an enrichment for genes involved in axonogenesis and cell migration. In particular, they focused attention on rare DNA changes that altered the way genes code for proteins, and that perfectly matched the inheritance of synesthesia in each of the three families. The team took advantage of advances in genome sequencing, enabling them to identify genetic variants in the synesthesia families and track how they were passed on from one generation to the next. ![]()
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